43 Oral Sildenafil in the Treatment of Erectile Dysfunction
Archived from the original on 14 January 2012. "Onset and duration of action of sildenafil for the treatment of erectile dysfunction".
- Women are generally not treated with sildenafil for sexual arousal.
- Research on sildenafil's effects on women is ongoing.
- Use in women should only occur under medical supervision.
^ "Scientist who developed Viagra receives knighthood in New Year's Honours". Archived from the original on 14 January 2023. "Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond". Archived from the original on 26 September 2008. Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments. Morriston Hospital in Swansea, was the first in the world to trial Viagra! ^ Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, et al. "Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction". "Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction". "Drug repositioning: identifying and developing new uses for existing drugs". Archived from the original on 22 April 2019. Archived from the original on 10 June 2019. "Health situation in former communist bloc is dire, says Unicef". Archived from the original on 1 November 2012.
| Parameter | Description | Typical Value | Notes |
|---|---|---|---|
| Absorption Rate | How quickly sildenafil enters bloodstream | Rapid | Peaks in 30-120 minutes |
| Bioavailability | Percentage of dose reaching systemic circulation | ~40% | Affected by food intake |
| Half-life | Time for plasma concentration to reduce by half | 3-5 hours | Determines dosing frequency |
| Peak Plasma Concentration | Maximum concentration after dose | 1 hour | Influenced by gastric emptying and food intake |
^ Gurevich M, Cormier N, Leedham U, Brown-Bowers A (August 2018). Sexuopharmaceutical use by men as prevention and proficiency".
Material and Methods
"Source: Roger Clemens, host of athletes pop Viagra to help onfield performance". Archived from the original on 14 August 2020. "Bears' Brandon Marshall says some NFL players use Viagra .. on the Field". Archived from the original on 5 March 2016.
Serious Side Effects (Rare)
"Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks". "Detection of sildenafil analogues in herbal products for erectile dysfunction". Archived from the original on 4 March 2016. ^ "FDA Warns Consumers About Dangerous Ingredients in "Dietary Supplements" Promoted for Sexual Enhancement". Archived from the original on 18 January 2017. "Spreading the Word, but What Word is That? Viagra and Male Sexuality in Popular Culture". "A new view of women's sexual problems: Why new? Archived from the original on 3 January 2009. Archived from the original on 12 October 2008. "Sales of Impotence Drugs Fall, Defying Expectations". Archived sildenafil tablets 125 from the original on 11 October 2007. ^ "Pfizer Courting More Controversy with Viagra 'Advergaming'". Archived from the original on 19 December 2019. Archived from the original on 6 May 2018. Archived from the original on 9 January 2009. Archived from the original on 22 February 2021. ^ a b "Viagra now available over the counter without prescription in the UK". Archived from the original on 26 March 2021. Archived from the original on 8 December 2013. "The coming generics threat to Pfizer's Viagra brand just got scarier". Archived from the original on 9 September 2017. ^ "Viagra to go generic in 2017 according to Pfizer agreement". Archived from the original on 1 December 2017. "Sex, Drugs and That Little Blue Pill".
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Oral Jelly | 100mg | 63 + 7 Sachets | 224.18€ 213.50€ | |
| Viagra Generic | 50mg | 90 + 6 Pills | 107.37€ 102.26€ | |
| Viagra Generic | 150mg | 20 Pills | 55.02€ 52.40€ | |
| Viagra Generic | 100mg | 30 + 4 Pills | 60.91€ 58.01€ | |
| Viagra Generic | 25mg | 20 Pills | 37.74€ 35.94€ | |
| Kamagra Polo | 100mg | 120 + 6 Pills | 327.15€ 311.57€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ | |
| Kamagra Polo | 100mg | 32 Pills | 125.88€ 119.89€ | |
| Kamagra Oral Jelly | 100mg | 10 Sachets | 54.55€ 51.95€ | |
| Viagra Generic | 150mg | 60 + 4 Pills | 111.25€ 105.95€ | |
| Kamagra Polo | 100mg | 20 Pills | 83.56€ 79.58€ | |
| Viagra Generic | 150mg | 30 + 2 Pills | 72.32€ 68.88€ | |
| Viagra Generic | 150mg | 10 Pills | 36.73€ 34.98€ | |
| Kamagra Soft Tabs | 100mg | 32 Pills | 120.11€ 114.39€ | |
| Viagra Generic | 25mg | 360 + 10 Pills | 213.68€ 203.50€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ |
Archived from the original on 6 December 2017. "Why Pfizer Is About to Slash Viagra's Price in Half". Archived from the original on 7 December 2017. "Pfizer to lose patent of drug Viagra, Indian companies gear up with copycat versions: Pfizer's patent for the formulation of Viagra, used to treat impotence in men, ends in the US in 2020". Archived from the original on 17 April 2021. ^ "Set to conquer US, Indian 'Viagras' may give Pfizer a hard Time". Archived from the original on 22 December 2020. ^ a b "Pfizer Settles Viagra® Patent Litigation With Teva". "Lockout Supplements Issues Voluntary Nationwide Recall of Boner Bears Chocolate Syrup Due to Undeclared Sildenafil".
Dosing & Uses
"Vision disorders and phosphodiesterase type 5 inhibitors: a review of the evidence to date". ^ "FDA Announces Revisions to Labels for Cialis, Levitra and Viagra". "Drug interactions with phosphodiesterase-5 inhibitors used for the treatment of erectile dysfunction or pulmonary hypertension". "Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions". Use of sildenafil (Viagra) in patients with cardiovascular disease.
Why Choose Sildenafil Drops?
American College of Cardiology/American Heart Association". Journal of the American College of Cardiology. ^ "Viagra (Sildenafil Citrate): Side Effects, Interactions, Warning, Dosage & Uses". Archived from the original on 12 July 2018. "Young men add Viagra to their drug arsenal". Archived from the original on 19 November 2016. "Counterfeit Viagra, Cialis, Levitra: The Ultimate Guide". Archived from the original on 10 January 2017. "Online pharmacies suspected of counterfeit drug sales". ^ "Erectile Dysfunction Medication the Most Seized Drug During Global Crackdown, Interpol Says". ^ "Global illicit medicines targeted by INTERPOL operation". Archived from the original on 10 December 2023. ^ "Israeli-made AI exposes international fake Viagra network".
Side Effects
Archived from the original on 4 September 2014. "Recreational use and misuse of phosphodiesterase 5 inhibitors". Archived from the original on 21 August 2016. "Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time". ^ McCambridge J, Mitcheson L, Hunt N, Winstock A (March 2006).
Medical Subject Headings Check Words
"The rise of Viagra among British illicit drug users: 5-year survey data". "Does marijuana use play a role in the recreational use of sildenafil?". Archived from the original on 26 January 2013. "Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules". Proceedings of the National Academy of Sciences of the United States of America. ^ "Counterfeit Viagra Pills, Footwear, Belts, Car Emblems and Headphones Worth over $32 Million Seized at the LA/Long Beach Seaport U.S. Customs and Border Protection". Archived from the original on 12 October 2013.
- Some men may experience minor flushing after taking sildenafil.
- If an adverse reaction occurs, stop medication and contact your doctor.
- Be aware of possible symptoms like sudden vision loss.
"Yes, There Is a Way to Get Generic Viagra". Archived from the original on 2 May 2016. "Pfizer Wins Viagra Patent Infringement Case Against Teva Pharmaceuticals".
Sildenafil Citrate 20 mg/mL, Oral Paste, 60mL Syringe
Food and Drug Administration (FDA). Archived from the original on 31 March 2021. Archived from the original on 12 August 2025. ^ "Sildenafil Drug Usage Statistics, United States, 2014 - 2023". "Generic Viagra: Two versions of sildenafil hit the market today".
Clinics in Endocrinology and Metabolism
Archived from the original on 25 November 2018. Archived from the original on 12 February 2022. "With Viagra Now Available Over-The-Counter In The U.K., Will The U.S. "Phosphodiesterase inhibitors for erectile dysfunction in patients with diabetes mellitus". "Strategies for managing sexual dysfunction induced by antidepressant medication". Archived from the original on 11 January 2015. ^ "Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan". Retrieved 17 June 2024 – via Business Wire.
How should I take sildenafil?
The Cochrane Database of Systematic Reviews (5) CD003382. Archived from the original on 10 October 2020. "Efficacy and safety of sildenafil treatment in pulmonary arterial hypertension: a systematic review". Archived from the original on 29 August 2021. "Raynaud's phenomenon and digital ischaemia--pharmacologic approach and alternative treatment options".
Does sildenafil cause different side effects in females?
"Efficacy of Sildenafil on healthy humans in high‑altitude hypoxia at rest and during exercise: A meta‑analysis". "Interventions for preventing high altitude illness: Part 1. Archived from the original on 10 June 2017. ^ "FDA Updates Labeling for Viagra, Cialis and Levitra for Rare Post-Marketing Reports of Eye Problems" (Press release). Archived from the original on 22 October 2016. Archived from the original on 17 June 2024. "Viagra patent expires in June, says Brazilian court". Archived from the original on 17 April 2012.
| Side Effect | Incidence (%) | Severity | Recommendations |
|---|---|---|---|
| Headache | 16-30 | Mild to moderate | Usually resolves spontaneously |
| Flushing | 10-15 | Mild | Can be reduced with lower doses |
| Dyspepsia | 10-20 | Mild | Take with food to reduce symptoms |
| Nasal Congestion | 10-20 | Mild | Usually transient |
| Visual Disturbances | 2-4 | Mild to moderate | Rare, discontinue if persistent |
^ "Revatio patent ruled invalid for lack of sound prediction and obviousness". Archived from the original on 3 March 2016. {{cite web}}: CS1 maint: deprecated archival service (link) ^ Teva Canada Ltd. v. Pfizer Canada Inc., 2012 SCC 60 at par. "Supreme Court ruling could lead to cheaper versions of Viagra".
- Take sildenafil on an empty stomach for faster absorption.
- High-fat meals may delay the effectiveness of the medication.
- Do not crush or chew sildenafil tablets; swallow whole.
Archived from the original on 10 March 2013.
Brand names
^ "Hidden Risks of Erectile Dysfunction 'Treatments' Sold Online". Archived from the original on 23 April 2019. ^ R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 9th edition, Biomedical Publications, Seal Beach, CA, 2011, pp. Archived from the original (PDF) on 10 September 2011. "Canadian Supreme court rules Viagra patent invalid". Archived from the original on 11 November 2012. ^ "Viagra patent tossed out by Supreme Court: Decision allows generic versions of drug to be produced".
| Medication Type | Potential Interaction | Effect | Notes |
|---|---|---|---|
| Nitrates | Severe hypotension | Dangerous drop in blood pressure | Absolute contraindication |
| Alpha-blockers | Enhanced hypotensive effect | Blood pressure may drop too low | Use with caution, monitor BP |
| CYP3A4 inhibitors | Increased sildenafil levels | Increased risk of side effects | Dose adjustment may be needed |
| Rifampin | Reduced sildenafil effectiveness | Lower plasma levels | May require dose increase |
Archived from the original on 18 September 2013. ^ "Pfizer Canada drops Viagra price after generic versions get Supreme Court green light". Archived from the original on 30 November 2012. Archived from the original on 27 December 2013. "In rare move, Pfizer asks Supreme Court to reconsider ruling that killed Viagra patent". Archived from the original on 5 February 2013. "The Supreme Court of Canada holds Pfizer's Viagra patent invalid". Archived from the original on 20 May 2013. ^ "Actavis Launches Generic Viagra in Europe as Patents Expire". Archived from the original on 29 October 2013. "What Will Happen When Viagra Goes Generic?". Archived from the original on 23 April 2011.
- Sildenafil's effects typically last for 4-6 hours.
- It does not increase sexual desire but enhances response.
- Onset of action can be affected by age and health status.
^ "Is Viagra about to lose its pulling power in the UK?". Archived from the original on 30 October 2013. Archived from the original on 22 August 2009. Archived from the original on 25 June 2007. "Viagra from the pharmacist: insight from reclassification in New Zealand".
Author information
"Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules". ^ a b Webb DJ, Freestone S, Allen MJ, Muirhead GJ (March 1999). "Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist". ^ Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA (May 1998). "Oral sildenafil in the treatment of erectile dysfunction. Archived from the original on 17 May 2021.
